Sulfonamide (sul-FON-ah-mide) and trimethoprim combinations are used to prevent and treat infections. Sulfadiazine and trimethoprim combination is used to treat urinary tract infections. Sulfamethoxazole and trimethoprim combination is used to treat infections, such as bronchitis, middle ear infection, urinary tract infection, and traveler's diarrhea. It is also used for the prevention and treatment of Pneumocystis carinii pneumonia (PCP). These medicines will not work for colds, flu, or other virus infections. They may also be used for other conditions as determined by your doctor.

Follow the directions for using this medicine provided by your doctor. TAKE THIS MEDICINE with a glass (8 ounces) of water. Drink several additional glasses of water daily unless otherwise directed by your doctor. STORE THIS MEDICINE at room temperature, away from heat and light. TO CLEAR UP YOUR INFECTION COMPLETELY, continue taking this medicine for the full course of treatment even if you feel better in a few days. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

SIDE EFFECTS, that may go away during treatment include stomach upset, nausea, vomiting, or loss of appetite. If they continue or are bothersome, check with your doctor. Rarely, this medicine can cause serious, even fatal, side effects such as a severe peeling skin rash known as Stevens-Johnson syndrome, blood disorders (e.g., agranulocytosis, aplastic anemia), or liver damage. CONTACT YOUR DOCTOR IMMEDIATELY if you experience skin rash or blisters, unusual fatigue, persistent sore throat or fever, yellowing eyes or skin, dark urine, or abdominal pain. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience hives, swelling of the tongue, joint pain, cough, shortness of breath, vaginal irritation or discharge, paleness, unusual bruising or bleeding. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea or vomiting, stomach pain, dizziness, drowsiness, confusion, depression, blood in urine, and loss of consciousness.

DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.

If you miss a dose of this medicine, take it as soon as possible. This will help to keep a constant amount of medicine in the blood or urine. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

This medicine is an antibiotic combination used to treat or prevent infections.

STORE THIS MEDICINE at room temperature, away from heat and light. TO CLEAR UP YOUR INFECTION COMPLETELY, continue taking this medicine for the full course of treatment even if you feel better in a few days.

It is very important that your doctor check your progress at regular visits. This medicine may cause blood problems, especially if it is taken for a long time.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

Sulfonamide and trimethoprim combinations may cause blood problems. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment.

Sulfonamide and trimethoprim combinations may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:

Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
Wear protective clothing, including a hat and sunglasses.
Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional.
Apply a sun block lipstick that has an SPF of at least 15 to protect your lips.
Do not use a sunlamp or tanning bed or booth.
If you have a severe reaction from the sun, check with your doctor.

This medicine may also cause some people to become dizzy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert . If this reaction is especially bothersome, check with your doctor.